bioinfomatics.md

BioInformatics

https://www.interactive-biosoftware.com/alamut-visual/video-tutorials/ https://varsome.com/variant/hg19/chr13-32937506-G-C

• Rosalind - learning bioinformatics and programming through problem solving
  • Transcribing DNA into RNA
  • Semiglobal Alignment
• Sequencing your DNA with a USB dongle and open source code

see history

• 30 Years Since the Human Genome Project Began, What’s Next?
  • Eric Green, head of the nation’s top genomics research institute, looks back on how far the field has come and shares his bold vision for the future.
  • Human Genome project 1990 to 2000 - 10 years to sequence the first human genome
    • racks of crt screens - computers only had a few megabytes of RAM not even gigabytes
    • The human genome is, at long last, complete 2022
      • in 2000 only 92% of main bits were sequenced. Some bits that did not directly create proteins were de-prioritised. Turns out the missing 8% was quite important to regulating other functions.

https://mpeg-g.org/

• NHS Genomic Medicine Service

• Google Images: Genome Viewer

  • Integrative Genomics Viewer - IGV in a webbrowser
  • geneious.com - professional desktop viewer (paid)

• Am I still lactose tolerant? - Lactose Gene Therapy Update

  • Code on GitHub
    • thethoughtemporium/Whose-gene-is-it-anyway

• Algorithm discovers how six simple molecules could evolve into life’s building blocks

• What is the “protein folding problem”? A brief explanation

• Mirror Bacteria Research Poses Significant Risks, Dozens of Scientists Warn - Synthetic biologists make artificial cells, but one particular kind isn’t worth the risk.

  • As synthetic biologists, we have spent the last few decades in awe of the breakthroughs in the field. In the last fifteen years, synthetic biologists have stored books, images, and even videos in DNA, developed the ability to modify and engineer genes with remarkable accuracy, and even created an organism with chromosome designed using a computer and synthesized in the lab.1-5

  • These advances have allowed us to develop effective drugs against diseases like malaria, innovate lightweight, biodegradable, and high-strength materials such as artificial spider silk, and bolster our understanding of how life forms.6-8 In many cases, these breakthroughs were unforeseen and would not have happened if scientists could not conduct their research freely.

  • bacteria-based self-healing concrete
  • Mirror bacteria would not consume sugars and protines that exist in the world. They could act on the raw components that the rest of life uses. There is no immune response that any life on earth could counter.

• I know genomes. Don't delete your DNA

  • Too many people are panicking about 23andMe.
  • HN Comments