diff --git a/README.md b/README.md
index f875f65dd6..af89adbb8c 100644
--- a/README.md
+++ b/README.md
@@ -31,7 +31,7 @@ Some reasons you might want to use REST framework:
 # Requirements
 
 * Python 3.10+
-* Django 4.2, 5.0, 5.1, 5.2, 6.0
+* Django 5.0, 5.1, 5.2, 6.0
 
 We **highly recommend** and only officially support the latest patch release of
 each Python and Django series.
diff --git a/docs/api-guide/fields.md b/docs/api-guide/fields.md
index ca63192888..890d7c813e 100644
--- a/docs/api-guide/fields.md
+++ b/docs/api-guide/fields.md
@@ -330,7 +330,7 @@ Corresponds to `django.db.models.fields.DateTimeField`.
 
 * `format` - A string representing the output format. If not specified, this defaults to the same value as the `DATETIME_FORMAT` settings key, which will be `'iso-8601'` unless set. Setting to a format string indicates that `to_representation` return values should be coerced to string output. Format strings are described below. Setting this value to `None` indicates that Python `datetime` objects should be returned by `to_representation`. In this case the datetime encoding will be determined by the renderer.
 * `input_formats` - A list of strings representing the input formats which may be used to parse the date.  If not specified, the `DATETIME_INPUT_FORMATS` setting will be used, which defaults to `['iso-8601']`.
-* `default_timezone` - A `tzinfo` subclass (`zoneinfo` or `pytz`) representing the timezone. If not specified and the `USE_TZ` setting is enabled, this defaults to the [current timezone][django-current-timezone]. If `USE_TZ` is disabled, then datetime objects will be naive.
+* `default_timezone` - A `tzinfo` subclass (`zoneinfo`) representing the timezone. If not specified and the `USE_TZ` setting is enabled, this defaults to the [current timezone][django-current-timezone]. If `USE_TZ` is disabled, then datetime objects will be naive.
 
 #### `DateTimeField` format strings.
 
diff --git a/docs/index.md b/docs/index.md
index 6efc1c19db..d2e2a9bf57 100644
--- a/docs/index.md
+++ b/docs/index.md
@@ -61,7 +61,7 @@ Some reasons you might want to use REST framework:
 
 REST framework requires the following:
 
-* Django (4.2, 5.0, 5.1, 5.2)
+* Django (5.0, 5.1, 5.2)
 * Python (3.10, 3.11, 3.12, 3.13, 3.14)
 
 We **highly recommend** and only officially support the latest patch release of
diff --git a/pyproject.toml b/pyproject.toml
index 121ac357f7..6e0c2c965a 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -14,7 +14,6 @@ classifiers = [
   "Development Status :: 5 - Production/Stable",
   "Environment :: Web Environment",
   "Framework :: Django",
-  "Framework :: Django :: 4.2",
   "Framework :: Django :: 5.0",
   "Framework :: Django :: 5.1",
   "Framework :: Django :: 5.2",
@@ -31,7 +30,7 @@ classifiers = [
   "Topic :: Internet :: WWW/HTTP",
 ]
 dynamic = [ "version" ]
-dependencies = [ "django>=4.2" ]
+dependencies = [ "django>=5.0" ]
 urls.Changelog = "https://www.django-rest-framework.org/community/release-notes/"
 urls.Funding = "https://fund.django-rest-framework.org/topics/funding/"
 urls.Homepage = "https://www.django-rest-framework.org"
@@ -51,8 +50,6 @@ test = [
   "pytest-cov==7.*",
   "pytest-django>=4.5.2,<5",
 
-  # Remove when dropping support for Django<5.0
-  "pytz",
 ]
 docs = [
   # MkDocs to build our documentation.
@@ -75,7 +72,6 @@ optional = [
   # setuptools is needed for coreapi (imports pkg_resources)
   "setuptools<82",
 ]
-django42 = [ "django>=4.2,<5.0" ]
 django50 = [ "django>=5.0,<5.1" ]
 django51 = [ "django>=5.1,<5.2" ]
 django52 = [ "django>=5.2,<6.0" ]
@@ -102,7 +98,7 @@ skip = [ ".tox" ]
 atomic = true
 multi_line_output = 5
 extra_standard_library = [ "types" ]
-known_third_party = [ "pytest", "_pytest", "django", "pytz", "uritemplate" ]
+known_third_party = [ "pytest", "_pytest", "django", "uritemplate" ]
 known_first_party = [ "rest_framework", "tests" ]
 
 [tool.codespell]
diff --git a/tests/test_fields.py b/tests/test_fields.py
index e360793184..4f9dd0c00b 100644
--- a/tests/test_fields.py
+++ b/tests/test_fields.py
@@ -9,9 +9,7 @@
 from unittest.mock import patch
 from zoneinfo import ZoneInfo
 
-import django
 import pytest
-import pytz
 from django.core.exceptions import ValidationError as DjangoValidationError
 from django.db.models import IntegerChoices, TextChoices
 from django.http import QueryDict
@@ -1646,7 +1644,7 @@ def setup_class(cls):
 
     def assertUTC(self, tzinfo):
         """
-        Check UTC for datetime.timezone, ZoneInfo, and pytz tzinfo instances.
+        Check UTC for datetime.timezone, ZoneInfo.
         """
         assert (
             tzinfo is utc or
@@ -1684,34 +1682,6 @@ def test_should_render_date_time_in_default_timezone(self):
         assert rendered_date == rendered_date_in_timezone
 
 
-@pytest.mark.skipif(
-    condition=django.VERSION >= (5,),
-    reason="Django 5.0 has removed pytz; this test should eventually be able to get removed.",
-)
-class TestPytzNaiveDayLightSavingTimeTimeZoneDateTimeField(FieldValues):
-    """
-    Invalid values for `DateTimeField` with datetime in DST shift (non-existing or ambiguous) and timezone with DST.
-    Timezone America/New_York has DST shift from 2017-03-12T02:00:00 to 2017-03-12T03:00:00 and
-     from 2017-11-05T02:00:00 to 2017-11-05T01:00:00 in 2017.
-    """
-    valid_inputs = {}
-    invalid_inputs = {
-        '2017-03-12T02:30:00': ['Invalid datetime for the timezone "America/New_York".'],
-        '2017-11-05T01:30:00': ['Invalid datetime for the timezone "America/New_York".']
-    }
-    outputs = {}
-
-    class MockTimezone(pytz.BaseTzInfo):
-        @staticmethod
-        def localize(value, is_dst):
-            raise pytz.InvalidTimeError()
-
-        def __str__(self):
-            return 'America/New_York'
-
-    field = serializers.DateTimeField(default_timezone=MockTimezone())
-
-
 @patch('rest_framework.utils.timezone.datetime_ambiguous', return_value=True)
 class TestNaiveDayLightSavingTimeTimeZoneDateTimeField(FieldValues):
     """
diff --git a/tox.ini b/tox.ini
index 00e5bd57b8..8eec6eb00c 100644
--- a/tox.ini
+++ b/tox.ini
@@ -1,8 +1,8 @@
 [tox]
 envlist =
-       {py310}-{django42,django51,django52}
-       {py311}-{django42,django51,django52}
-       {py312}-{django42,django51,django52,django60,djangomain}
+       {py310}-{django51,django52}
+       {py311}-{django51,django52}
+       {py312}-{django51,django52,django60,djangomain}
        {py313}-{django51,django52,django60,djangomain}
        {py314}-{django52,django60,djangomain}
        base
@@ -18,7 +18,6 @@ setenv =
 dependency_groups =
        test
        optional
-       django42: django42
        django50: django50
        django51: django51
        django52: django52