diff --git a/packages/react-native/Libraries/Blob/FileReader.js b/packages/react-native/Libraries/Blob/FileReader.js
index 9cb37e5ca487..4e2ea12d80f3 100644
--- a/packages/react-native/Libraries/Blob/FileReader.js
+++ b/packages/react-native/Libraries/Blob/FileReader.js
@@ -86,7 +86,7 @@ class FileReader extends EventTarget {
           return;
         }
 
-        const base64 = text.split(',')[1];
+        const base64 = text.split(',')[1] ?? '';
         const typedArray = toByteArray(base64);
 
         this._result = typedArray.buffer;