diff --git a/doc/benchmark.conf.sample b/doc/benchmark.conf.sample
index 97bc5985..8b2c72df 100644
--- a/doc/benchmark.conf.sample
+++ b/doc/benchmark.conf.sample
@@ -51,6 +51,9 @@ pgo = True
 #   PYTHON_JIT=0 can be used to disable the micro-op interpreter at runtime.
 jit = no
 
+# Tail-calling interpreter?
+tail_call_interp = False
+
 # The space-separated list of libraries that are package-only,
 # i.e., locally installed but not on header and library paths.
 # For each such library, determine the install path and add an
diff --git a/pyperformance/compile.py b/pyperformance/compile.py
index 54219f06..c96dc4e0 100644
--- a/pyperformance/compile.py
+++ b/pyperformance/compile.py
@@ -295,6 +295,8 @@ def compile(self):
             config_args.append("--with-lto")
         if self.conf.jit:
             config_args.append(f"--enable-experimental-jit={self.conf.jit}")
+        if self.conf.tail_call_interp:
+            config_args.append("--with-tail-call-interp")
         if self.conf.pkg_only:
             config_args.extend(self.get_package_only_flags())
         if self.conf.debug:
@@ -830,6 +832,7 @@ def getint(section, key, default=None):
         conf.lto = getboolean("compile", "lto", True)
         conf.pgo = getboolean("compile", "pgo", True)
         conf.jit = getstr("compile", "jit", "")
+        conf.tail_call_interp = getboolean("compile", "tail_call_interp", False)
         conf.install = getboolean("compile", "install", True)
         conf.pkg_only = getstr("compile", "pkg_only", "").split()
         try:
diff --git a/pyperformance/tests/test_compile.py b/pyperformance/tests/test_compile.py
new file mode 100644
index 00000000..1c178d51
--- /dev/null
+++ b/pyperformance/tests/test_compile.py
@@ -0,0 +1,73 @@
+import os
+import pathlib
+import tempfile
+import textwrap
+import types
+import unittest
+from unittest import mock
+
+from pyperformance import compile as compile_mod
+
+
+class ParseConfigTests(unittest.TestCase):
+    def test_parse_config_reads_tail_call_interp(self):
+        with tempfile.TemporaryDirectory() as tmpdir:
+            root = pathlib.Path(tmpdir)
+            config_path = root / "benchmark.conf"
+            config_path.write_text(
+                textwrap.dedent(
+                    f"""\
+                    [config]
+                    json_dir = {root / "json"}
+
+                    [scm]
+                    repo_dir = {root / "cpython"}
+
+                    [compile]
+                    bench_dir = {root / "bench"}
+                    tail_call_interp = true
+
+                    [run_benchmark]
+                    """
+                ),
+                encoding="utf-8",
+            )
+
+            conf = compile_mod.parse_config(str(config_path), "compile")
+
+            self.assertTrue(conf.tail_call_interp)
+
+
+class CompileCommandTests(unittest.TestCase):
+    def test_compile_adds_tail_call_interp_flag(self):
+        conf = types.SimpleNamespace(
+            build_dir="/tmp/build",
+            repo_dir="/tmp/cpython",
+            prefix="",
+            debug=False,
+            lto=False,
+            pgo=True,
+            jit="",
+            tail_call_interp=True,
+            pkg_only=[],
+            jobs=0,
+        )
+        app = types.SimpleNamespace(
+            branch="main",
+            logger=None,
+            safe_makedirs=mock.Mock(),
+            run=mock.Mock(),
+        )
+
+        compile_mod.Python(app, conf).compile()
+
+        configure_call = app.run.call_args_list[0]
+        self.assertEqual(
+            configure_call.args,
+            (os.path.join(conf.repo_dir, "configure"), "--with-tail-call-interp"),
+        )
+        self.assertEqual(configure_call.kwargs, {"cwd": "/tmp/build"})
+
+
+if __name__ == "__main__":
+    unittest.main()