diff --git a/number.go b/number.go
index a58dc4d..51e09ed 100644
--- a/number.go
+++ b/number.go
@@ -414,12 +414,38 @@ func parseInt[T integer](s string) (T, error) {
 }
 
 func parseUint[T unsigned](s string) (T, error) {
-	v, err := strconv.ParseUint(strings.TrimLeft(trimDecimal(s), "+"), 0, 0)
-	if err != nil {
-		return 0, err
+	s = strings.TrimLeft(trimDecimal(s), "+")
+	v, err := strconv.ParseUint(s, 0, 0)
+	if err == nil {
+		return T(v), nil
+	}
+	if isLikelyHexString(s) {
+		v, err = strconv.ParseUint(s, 16, 0)
+		if err == nil {
+			return T(v), nil
+		}
 	}
 
-	return T(v), nil
+	return 0, err
+}
+
+func isLikelyHexString(s string) bool {
+	if s == "" {
+		return false
+	}
+	hasLetter := false
+	for _, r := range s {
+		switch {
+		case r >= '0' && r <= '9':
+		case r >= 'a' && r <= 'f':
+			hasLetter = true
+		case r >= 'A' && r <= 'F':
+			hasLetter = true
+		default:
+			return false
+		}
+	}
+	return hasLetter
 }
 
 func parseFloat[T float](s string) (T, error) {
diff --git a/number_test.go b/number_test.go
index 9d84d18..8c62a34 100644
--- a/number_test.go
+++ b/number_test.go
@@ -390,6 +390,21 @@ func TestNumber(t *testing.T) {
 	}
 }
 
+func TestIssue334_HexStringToUint64(t *testing.T) {
+	c := qt.New(t)
+
+	const hex = "882d5422d5fffff"
+	const want uint64 = 613286979481632767
+
+	c.Assert(cast.ToUint64(hex), qt.Equals, want)
+
+	got, err := cast.ToUint64E(hex)
+	c.Assert(err, qt.IsNil)
+	c.Assert(got, qt.Equals, want)
+
+	c.Assert(cast.ToUint64("0x"+hex), qt.Equals, want)
+}
+
 func BenchmarkNumber(b *testing.B) {
 	type testCase struct {
 		name     string