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MKoesters/README.md

Hey, I’m Manuel

Cloud engineer and bioinformatician at DKFZ in Heidelberg, working on GHGA — Germany’s national infrastructure for sharing sensitive human genomic data.

My background is in computational biology (PhD on tRNA modifications and protein turnover), but I’ve spent the last few years moving closer to the infrastructure side: cloud platforms, data pipelines, and bioinformatics workflows at scale.


What I work on

  • Genomics infrastructure — secure data storage, access control, and processing of omics data following GA4GH standards
  • Trusted research environments — building cloud-based TREs that let researchers work with sensitive genomic data without it ever leaving a controlled environment
  • Bioinformatics pipelines — Nextflow, Dataflow, and whatever the data actually needs
  • Cloud & DevOps — AWS / GCP, Terraform / Pulumi, containers, CI/CD
  • Proteomics tooling — maintaining open source libraries for mass spectrometry data

Open source contributions

Proteomics / mass spectrometry

Repo What it does
pymzml/pymzML Python interface for mzML mass spectrometry files — published in Bioinformatics 2018
computational-ms/pyiohat I/O handler for peptide search engine results
computational-ms/unify_idents Unifies peptide identifications across search engines
ursgal/ursgal Wrapper framework for proteomics tools
computational-ms/unimod-mapper UniMod modification mapping
LeidelLab/SMITER Synthetic mzML writer for benchmarking — published in Genes 2021
computational-ms/chemical-composition Chemical formula handling for mass spec
pyqms/pyqms Fast mass spectrometry quantification

Parameter & metadata tooling

Repo What it does
urgap/urgap Unified resource governance and data provenance
uparma/uparma-lib Unified parameter mapper for bioinformatics tools
uparma/uparma-py Python client for uparma-lib

Infrastructure

Repo What it does
ghga-de/charts Helm charts for GHGA Kubernetes infrastructure

Currently learning

Rust. Slowly.


If you work on TREs, genomics data infrastructure, or computational mass spectrometry and want to exchange ideas, feel free to reach out.

📫 manuel.koesters@dkfz-heidelberg.de

Pinned Loading

  1. pymzml/pymzML pymzml/pymzML Public

    pymzML - an interface between Python and mzML Mass spectrometry Files

    Python 185 95

  2. ursgal/ursgal ursgal/ursgal Public

    Ursgal - universal Python module combining common bottom-up proteomics tools for large-scale analysis

    Python 45 31

  3. mobiusklein/pynumpress mobiusklein/pynumpress Public

    A thin, more convenient wrapper around MSNumpress

    C++ 1 2

  4. SMITER SMITER Public

    Synthetic Mzml wrITER

    Python 5

  5. pyQms/pyqms pyQms/pyqms Public

    pyQms, generalized, fast and accurate mass spectrometry data quantification

    Python 28 9